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Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats
Joint Authors
Azizi, Ayob
Kamisah, Yusof
Othman, Faizah
Asmadi, Ahmad Yusof
Norsidah, Ku-Zaifah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study investigated the effects of palm tocotrienol-rich fraction (TRF) on aortic proatherosclerotic changes in rats fed with a high methionine diet.
Forty-two male Wistar rats were divided into six groups.
The first group was the control (fed with a basal diet).
Another five groups were fed with 1% methionine diet for 10 weeks.
From week 6 onward, folate (8 mg/kg diet) or palm TRF (30, 60, and 150 mg/kg diets) was added into the diet of the last four rat groups, respectively.
The high methionine diet raised the plasma total homocysteine and aortic lipid peroxidation, which were reduced by the palm TRF and folate supplementations.
Plasma nitric oxide was reduced in the high methionine group compared to the control (3.72±0.57 versus 6.65±0.53 μmol/L, P<0.05), which reduction was reversed by the palm TRF (60 and 150 mg/kg) and folate supplementations.
The increased aortic vascular cell adhesion molecule-1 expression in the methionine group (2.58±0.29) was significantly reduced by the folate (1.38±0.18) and palm TRF at 150 mg/kg (1.19±0.23).
Palm TRF was comparable to folate in reducing high methionine diet-induced plasma hyperhomocysteinemia, aortic oxidative stress, and inflammatory changes in rats.
American Psychological Association (APA)
Norsidah, Ku-Zaifah& Asmadi, Ahmad Yusof& Azizi, Ayob& Othman, Faizah& Kamisah, Yusof. 2013. Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513000
Modern Language Association (MLA)
Norsidah, Ku-Zaifah…[et al.]. Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-513000
American Medical Association (AMA)
Norsidah, Ku-Zaifah& Asmadi, Ahmad Yusof& Azizi, Ayob& Othman, Faizah& Kamisah, Yusof. Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513000