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Important Roles of Cellular MicroRNA miR-155 in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Human T-cell leukemia virus type 1 (HTLV-1) is the pathogen that causes the aggressive and lethal malignancy of CD4+ T-lymphocytes called adult T-cell leukemia/lymphoma (ATLL).
MicroRNAs (miRNAs), a class of short, noncoding RNAs, regulate gene expression by targeting mRNAs for translational repression or cleavage.
miRNAs are involved in many aspects of cell biology linked with formation of several cancer phenotypes.
However, the relation between miRNAs and pathologic implication in ATLL is not well elucidated.
Here, we evaluated the roles of cellular miRNAs in ATLL caused by HTLV-1.
We found that the expression of miR-155 was increased in HTLV-1-positive T-cell lines.
miR-155 expression was enhanced by Tax and binding of transcription factors, NF-κB and AP-1, on the transcription binding sites of miR-155 gene promoter region is important to increase the expression of miR-155 by Tax.
Transfection of anti-miR-155 inhibitor, which inhibits the function of miR-155, inhibited the growth of HTLV-1-positive T-cell lines.
On the other hand, the growth of HTLV-1-negative T-cell lines was not changed by transfection of anti-miR-155.
Forced expression of miR-155 enhanced the growth of HTLV-1-positive T-cell lines.
These findings indicate that targeting the functions of miRNAs is a novel approach to the prevention or treatment of ATLL.
American Psychological Association (APA)
Tomita, Mariko. 2012. Important Roles of Cellular MicroRNA miR-155 in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection. ISRN Microbiology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-513057
Modern Language Association (MLA)
Tomita, Mariko. Important Roles of Cellular MicroRNA miR-155 in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection. ISRN Microbiology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-513057
American Medical Association (AMA)
Tomita, Mariko. Important Roles of Cellular MicroRNA miR-155 in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection. ISRN Microbiology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-513057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513057