A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease
Joint Authors
Proctor, Carole J.
Gray, Douglas A.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer's disease (AD) is characterised by the aggregation of two quite different proteins, namely, amyloid-beta (Aβ), which forms extracellular plaques, and tau, the main component of cytoplasmic neurofibrillary tangles.
The amyloid hypothesis proposes that Aβ plaques precede tangle formation but there is still much controversy concerning the order of events and the linkage between Aβ and tau alterations is still unknown.
Mathematical modelling has become an essential tool for generating and evaluating hypotheses involving complex systems.
We have therefore used this approach to discover the most probable pathway linking Aβ and tau.
The model supports a complex pathway linking Aβ and tau via GSK3β, p53, and oxidative stress.
Importantly, the pathway contains a cycle with multiple points of entry.
It is this property of the pathway which enables the model to be consistent with both the amyloid hypothesis for familial AD and a more complex pathway for sporadic forms.
American Psychological Association (APA)
Proctor, Carole J.& Gray, Douglas A.. 2012. A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513077
Modern Language Association (MLA)
Proctor, Carole J.& Gray, Douglas A.. A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513077
American Medical Association (AMA)
Proctor, Carole J.& Gray, Douglas A.. A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513077