Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes
Joint Authors
Ihara, Masafumi
Tomimoto, Hidekazu
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
With the demographic shift in age in advanced countries inexorably set to progress in the 21st century, dementia will become one of the most important health problems worldwide.
Vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease and is frequently responsible for the cognitive decline of the elderly.
It is characterized by cerebrovascular white matter changes; thus, in order to investigate the underlying mechanisms involved in white matter changes, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils.
The purpose of this paper is to provide a comprehensive summary of the achievements made with the model that shows good reproducibility of the white matter changes characterized by blood-brain barrier disruption, glial activation, oxidative stress, and oligodendrocyte loss following chronic cerebral hypoperfusion.
Detailed characterization of this model may help to decipher the substrates associated with impaired memory and move toward a more integrated therapy of vascular cognitive impairment.
American Psychological Association (APA)
Ihara, Masafumi& Tomimoto, Hidekazu. 2011. Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-513080
Modern Language Association (MLA)
Ihara, Masafumi& Tomimoto, Hidekazu. Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes. Journal of Aging Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-513080
American Medical Association (AMA)
Ihara, Masafumi& Tomimoto, Hidekazu. Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-513080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513080