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Biomechanical Influence of Cartilage Homeostasis in Health and Disease
Joint Authors
Chowdhury, T. T.
Salter, D. M.
Bader, D. L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
There is an urgent demand for long term solutions to improve osteoarthritis treatments in the ageing population.
There are drugs that control the pain but none that stop the progression of the disease in a safe and efficient way.
Increased intervention efforts, augmented by early diagnosis and integrated biophysical therapies are therefore needed.
Unfortunately, progress has been hampered due to the wide variety of experimental models which examine the effect of mechanical stimuli and inflammatory mediators on signal transduction pathways.
Our understanding of the early mechanopathophysiology is poor, particularly the way in which mechanical stimuli influences cell function and regulates matrix synthesis.
This makes it difficult to identify reliable targets and design new therapies.
In addition, the effect of mechanical loading on matrix turnover is dependent on the nature of the mechanical stimulus.
Accumulating evidence suggests that moderate mechanical loading helps to maintain cartilage integrity with a low turnover of matrix constituents.
In contrast, nonphysiological mechanical signals are associated with increased cartilage damage and degenerative changes.
This review will discuss the pathways regulated by compressive loading regimes and inflammatory signals in animal and in vitro 3D models.
Identification of the chondroprotective pathways will reveal novel targets for osteoarthritis treatments.
American Psychological Association (APA)
Bader, D. L.& Salter, D. M.& Chowdhury, T. T.. 2011. Biomechanical Influence of Cartilage Homeostasis in Health and Disease. Arthritis،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-513096
Modern Language Association (MLA)
Bader, D. L.…[et al.]. Biomechanical Influence of Cartilage Homeostasis in Health and Disease. Arthritis No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-513096
American Medical Association (AMA)
Bader, D. L.& Salter, D. M.& Chowdhury, T. T.. Biomechanical Influence of Cartilage Homeostasis in Health and Disease. Arthritis. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-513096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513096