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Surgical Castration in Hormone-Refractory Metastatic Prostate Cancer Patients Can Be an Alternative for Medical Castration
Joint Authors
Takeuchi, Takumi
Yamanoi, Mariko
Imao, Sadao
Tonooka, Akiko
Takeshima, Yuta
Mikami, Koji
Okamoto, Naohiko
Zaitsu, Masayoshi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Most patients with metastatic prostate cancer are endocrinologically treated with LHRH agonist, but finally castration-refractory and hormone-refractory cancers occur.
Serum testosterone levels get low to “the castration level” by LHRH agonists but may not get low enough against castration-refractory prostate cancer.
Methods.
As case series, twelve patients suffering from hormone-refractory prostate cancer continuously on LHRH agonist underwent surgical castration.
Additionally, one hundred and thirty-nine prostate cancer patients on LHRH agonist or surgical castration were tested for serum total testosterone levels.
Results.
Surgical castration caused decrease in serum PSA in one out of 12 hormone-refractory prostate cancer patients with PSA reduction rate 74%.
Serum total testosterone levels were below the sensitivity threshold (0.05 ng/mL) in 40 of 89 (44.9%) medically castrated patients and 33 of 50 (66.0%) surgically castrated patients (P=.20).
Conclusion.
Even hormone-refractory prostate cancer patients are candidates for surgical castration because of endocrinological, oncological, and economical reasons.
American Psychological Association (APA)
Zaitsu, Masayoshi& Yamanoi, Mariko& Mikami, Koji& Takeshima, Yuta& Okamoto, Naohiko& Imao, Sadao…[et al.]. 2011. Surgical Castration in Hormone-Refractory Metastatic Prostate Cancer Patients Can Be an Alternative for Medical Castration. Advances in Urology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513101
Modern Language Association (MLA)
Zaitsu, Masayoshi…[et al.]. Surgical Castration in Hormone-Refractory Metastatic Prostate Cancer Patients Can Be an Alternative for Medical Castration. Advances in Urology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-513101
American Medical Association (AMA)
Zaitsu, Masayoshi& Yamanoi, Mariko& Mikami, Koji& Takeshima, Yuta& Okamoto, Naohiko& Imao, Sadao…[et al.]. Surgical Castration in Hormone-Refractory Metastatic Prostate Cancer Patients Can Be an Alternative for Medical Castration. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513101