Genetic Mutations and Mitochondrial Toxins Shed New Light on the Pathogenesis of Parkinson's Disease
Joint Authors
Hattori, Nobutaka
Sato, Shigeto
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The cellular abnormalities in Parkinson's disease (PD) include mitochondrial dysfunction and oxidative damage, which are probably induced by both genetic predisposition and environmental factors.
Mitochondrial dysfunction has long been implicated in the pathogenesis of PD.
The recent discovery of genes associated with the etiology of familial PD has emphasized the role of mitochondrial dysfunction in PD.
The discovery and increasing knowledge of the function of PINK1 and parkin, which are associated with the mitochondria, have also enhanced the understanding of cellular functions.
The PINK1-parkin pathway is associated with quality control of the mitochondria, as determined in cultured cells treated with the mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP), which causes mitochondrial depolarization.
To date, the use of mitochondrial toxins, for example, 1-methyl-4-phynyl-tetrahydropyridine (MPTP) and CCCP, has contributed to our understanding of PD.
We review how these toxins and familial PD gene products are associated with and have enhanced our understanding of the role of mitochondrial dysfunction in PD.
American Psychological Association (APA)
Sato, Shigeto& Hattori, Nobutaka. 2011. Genetic Mutations and Mitochondrial Toxins Shed New Light on the Pathogenesis of Parkinson's Disease. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513109
Modern Language Association (MLA)
Sato, Shigeto& Hattori, Nobutaka. Genetic Mutations and Mitochondrial Toxins Shed New Light on the Pathogenesis of Parkinson's Disease. The Scientific World Journal No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-513109
American Medical Association (AMA)
Sato, Shigeto& Hattori, Nobutaka. Genetic Mutations and Mitochondrial Toxins Shed New Light on the Pathogenesis of Parkinson's Disease. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513109