A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population
Joint Authors
Shi, Dongquan
Teng, Huajian
Hao, Zheng
Jiang, Qing
Dai, Jin
Xu, Zhihong
Xu, Xingquan
Chen, Dongyang
Sun, Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Developmental dysplasia of the hip (DDH) is a common developmental hip disorder, which ranges from mild acetabulum malformation to irreducible hip dislocation.
A previous study suggested a significant association of pregnancy-associated plasma protein-A2 (PAPPA2) with DDH susceptibility in Chinese Han population.
But with the consideration of the sample size, the association was still debatable.
To confirm the association of the reported single nucleotide polymorphism (SNP) in PAPPA2, rs726252 with DDH, we conducted a case-control study in a larger number of subjects.
We genotyped rs726252 in 697 DDH subjects and 707 control subjects by TaqMan assay.
The association between this SNP and DDH was evaluated statistically.
No significant difference was found in any comparison of genotype distribution nor allele frequency between cases and controls.
Our replication study indicated that the association between rs726252 and DDH in Chinese Han population was debatable.
The association between PAPPA2 and DDH should be evaluated by additional studies.
American Psychological Association (APA)
Shi, Dongquan& Sun, Wei& Xu, Xingquan& Hao, Zheng& Dai, Jin& Xu, Zhihong…[et al.]. 2014. A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-513126
Modern Language Association (MLA)
Shi, Dongquan…[et al.]. A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-513126
American Medical Association (AMA)
Shi, Dongquan& Sun, Wei& Xu, Xingquan& Hao, Zheng& Dai, Jin& Xu, Zhihong…[et al.]. A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-513126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513126