Mammary Ductal Carcinoma In Situ : A Fresh Look at Architectural Patterns
Joint Authors
Scripcaru, Gabriel
Zardawi, Ibrahim M.
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Mammary ductal carcinoma in-situ (DCIS), a malignant appearing lesion on cytological and histological grounds, is in fact a non-obligate precancer.
DCIS is difficult to manage and is sometimes treated more aggressively than invasive carcinoma.
Although most DCIS classifications take into account the architectural growth pattern, when it comes to architecture, the literature is full of contradictory information.
We examined 289 breast cancers and found DCIS in 265 of the cases.
The majority of the DCIS cases were seen in the setting of invasive cancer and only 9% of the cases represented pure DCIS with no invasive cancer.
The DCIS commonly displayed a mixed pattern with micropapillary, cribriform and solid components with the micropapillary type being the rarest, occurring seldom on its own.
A continuum of growth with a micropapillary pattern evolving into a cribriform type could be seen in some of the cases.
This may explain some of the conflicting information, in the literature, regarding the different architectural types of DCIS.
The comedo-pattern of necrosis could be seen in all types of DCIS.
We therefore conclude that the study of the determinants of growth pattern in DCIS would be the key to unravelling the diverse, often non-concordant evidence one encounters in the literature.
American Psychological Association (APA)
Scripcaru, Gabriel& Zardawi, Ibrahim M.. 2012. Mammary Ductal Carcinoma In Situ : A Fresh Look at Architectural Patterns. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513127
Modern Language Association (MLA)
Scripcaru, Gabriel& Zardawi, Ibrahim M.. Mammary Ductal Carcinoma In Situ : A Fresh Look at Architectural Patterns. International Journal of Surgical Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-513127
American Medical Association (AMA)
Scripcaru, Gabriel& Zardawi, Ibrahim M.. Mammary Ductal Carcinoma In Situ : A Fresh Look at Architectural Patterns. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513127