Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood
Joint Authors
Attia, M. S.
Bassiouny, K.
Hamed, E.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The absorption efficiency of any drug in blood is of prime importance.
Compounds having the general formula: Kn[M(FO)2(H2O)2]⋅xH2O, where (M=Cu(II) or Fe(III), n=2 or 1 , FO=folate anion, x=2 or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined.
The obtained compounds were characterized by elemental analysis, infrared as well as thermogravimetric analysis and polarization of light.
The results suggest that the two folate complexes were formed in 1 : 2 molar ratio (metal : folic acid) which acted as a bidentate ligand through both carboxylic groups.
Polarization of light proved that the folate complexes have symmetric geometry.
Biological application proved that Cu(II) and Fe(III) complexes were absorbed more efficiently in rodent blood than folic acid itself.
American Psychological Association (APA)
Hamed, E.& Attia, M. S.& Bassiouny, K.. 2009. Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-513140
Modern Language Association (MLA)
Hamed, E.…[et al.]. Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-513140
American Medical Association (AMA)
Hamed, E.& Attia, M. S.& Bassiouny, K.. Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-513140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513140