Dynamic Association between HIV-1 Gag and Membrane Domains
Joint Authors
Llewellyn, G. Nicholas
Ono, Akira
Hogue, Ian B.
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
HIV-1 particle assembly is driven by the structural protein Gag.
Gag binds to and multimerizes on the inner leaflet of the plasma membrane, eventually resulting in formation of spherical particles.
During virus spread among T cells, Gag accumulates to the plasma membrane domain that, together with target cell membrane, forms a cell junction known as the virological synapse.
While Gag association with plasma membrane microdomains has been implicated in virus assembly and cell-to-cell transmission, recent studies suggest that, rather than merely accumulating to pre-existing microdomains, Gag plays an active role in reorganizing the microdomains via its multimerization activity.
In this paper, we will discuss this emerging view of Gag microdomain interactions.
Relationships between Gag multimerization and microdomain association will be further discussed in the context of Gag localization to T-cell uropods and virological synapses.
American Psychological Association (APA)
Hogue, Ian B.& Llewellyn, G. Nicholas& Ono, Akira. 2012. Dynamic Association between HIV-1 Gag and Membrane Domains. Molecular Biology International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-513148
Modern Language Association (MLA)
Hogue, Ian B.…[et al.]. Dynamic Association between HIV-1 Gag and Membrane Domains. Molecular Biology International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-513148
American Medical Association (AMA)
Hogue, Ian B.& Llewellyn, G. Nicholas& Ono, Akira. Dynamic Association between HIV-1 Gag and Membrane Domains. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-513148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513148