Test-Retest Reliability of a New Medial Temporal Atrophy Morphological Metric
Joint Authors
Mouiha, Abderazzak
Valdivia, Fernando
Duchesne, Simon
Robitaille, Nicolas
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Clinicians and researchers alike are in need of quantitative and robust measurement tools to assess medial temporal lobe atrophy (MTA) due to Alzheimer’s disease (AD).
We recently proposed a morphological metric, extracted from T1-weighted magnetic resonance images (MRI), to track and estimate MTA in cohorts of controls, AD, and mild cognitive impairment subjects, at high-risk of progression to dementia.
In this paper, we investigated its reliability through analysis of within-session scan/repeat images and scan/rescans from large multicenter studies.
In total, we used MRI data from 1051 subjects recruited at over 60 centers.
We processed the data identically and calculated our metric for each individual, based on the concept of distance in a high-dimensional space of intensity and shape characteristics.
Over 759 subjects, the scan/repeat change in the mean was 1.97% (SD: 21.2%).
Over three subjects, the scan/rescan change in the mean was 0.89% (SD: 22.1%).
At this level, the minimum trial size required to detect this difference is 68 individuals for both samples.
Our scan/repeat and scan/rescan results demonstrate that our MTA assessment metric shows high reliability, a necessary component of validity.
American Psychological Association (APA)
Duchesne, Simon& Valdivia, Fernando& Mouiha, Abderazzak& Robitaille, Nicolas. 2012. Test-Retest Reliability of a New Medial Temporal Atrophy Morphological Metric. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513149
Modern Language Association (MLA)
Duchesne, Simon…[et al.]. Test-Retest Reliability of a New Medial Temporal Atrophy Morphological Metric. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-513149
American Medical Association (AMA)
Duchesne, Simon& Valdivia, Fernando& Mouiha, Abderazzak& Robitaille, Nicolas. Test-Retest Reliability of a New Medial Temporal Atrophy Morphological Metric. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513149