![](/images/graphics-bg.png)
Polychlorinated Biphenyls-Induced Oxidative Stress on Rat Hippocampus : A Neuroprotective Role of Quercetin
Joint Authors
Venkataraman, Prabhu
Krishnamoorthy, Gunasekaran
Bavithra, Senthamilselvan
Selvakumar, Kandaswamy
Arunakaran, Jagadeesan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Present study is aimed to evaluate the ameliorative role of quercetin on PCBs-induced oxidative stress in hippocampus of Wistar rats.
Group I rats received vehicle (corn oil) intraperitoneally (i.p); Group II received quercetin 50 mg/kg bwt/day (gavage); Group III received PCB 2 mg/kg bwt/day (i.p); Group IV received PCB (i.p) and simultaneously quercetin through gavage.
After 30 days, rats were euthanized and hippocampus was dissected from each rat brain.
Oxidative stress was assessed by determining the levels of H2O2, LPO, Pcc, and alteration in the functional markers such as CK, AchE, and ATPases activities in the hippocampus of control and experimental animals.
A significant increase in the levels of stress markers and decrease in level of functional markers were observed in PCBs-treated rats.
Moreover DNA fragmentation and histological studies were ascertained to confirm PCBs toxicity.
In conclusion, quercetin shows a protective role against PCBs-induced oxidative damage in rat hippocampus.
American Psychological Association (APA)
Selvakumar, Kandaswamy& Bavithra, Senthamilselvan& Krishnamoorthy, Gunasekaran& Venkataraman, Prabhu& Arunakaran, Jagadeesan. 2012. Polychlorinated Biphenyls-Induced Oxidative Stress on Rat Hippocampus : A Neuroprotective Role of Quercetin. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513184
Modern Language Association (MLA)
Selvakumar, Kandaswamy…[et al.]. Polychlorinated Biphenyls-Induced Oxidative Stress on Rat Hippocampus : A Neuroprotective Role of Quercetin. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-513184
American Medical Association (AMA)
Selvakumar, Kandaswamy& Bavithra, Senthamilselvan& Krishnamoorthy, Gunasekaran& Venkataraman, Prabhu& Arunakaran, Jagadeesan. Polychlorinated Biphenyls-Induced Oxidative Stress on Rat Hippocampus : A Neuroprotective Role of Quercetin. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513184