Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages
Joint Authors
Philippidis, Pandelis
Haskard, Dorian O.
Boyle, Joseph J.
Domin, Jan
Landis, Robert Clive
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Intraplaque hemorrhage causes adaptive remodelling of macrophages towards a protective phenotype specialized towards handling iron and lipid overload, denoted Mhem.
The Mhem phenotype expresses elevated levels of hemoglobin (Hb) scavenger receptor, CD163, capable of endocytosing pro-oxidant free Hb complexed to acute phase protein haptoglobin (Hp).
It is notable that individuals homozygous for the Hp 2 allele (a poorer antioxidant) are at increased risk of cardiovascular disease compared to the Hp 1 allele.
In this study, we examined whether scavenging of polymorphic Hp:Hb complexes differentially generated downstream anti-inflammatory signals in cultured human macrophages culminating in interleukin (IL)-10 secretion.
We describe an anti-inflammatory signalling pathway involving phosphatidylinositol-3-kinase activation upstream of Akt phosphorylation (pSer473Akt) and IL-10 secretion.
The pathway is mediated specifically through CD163 and is blocked by anti-CD163 antibody or phagocytosis inhibitor.
However, levels of pSer473Akt and IL-10 were significantly diminished when scavenging polymorphic Hp2-2:Hb complexes compared to Hp1-1:Hb complexes (P<0.05).
Impaired anti-inflammatory macrophage signaling through a CD163/pAkt/IL-10 axis may thus represent a possible Hp2-2 disease mechanism in atherosclerosis.
American Psychological Association (APA)
Landis, Robert Clive& Philippidis, Pandelis& Domin, Jan& Boyle, Joseph J.& Haskard, Dorian O.. 2013. Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-513188
Modern Language Association (MLA)
Landis, Robert Clive…[et al.]. Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages. International Journal of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-513188
American Medical Association (AMA)
Landis, Robert Clive& Philippidis, Pandelis& Domin, Jan& Boyle, Joseph J.& Haskard, Dorian O.. Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-513188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513188