Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese : Cross-Sectional Data from the J-MICC Study
Joint Authors
Hamajima, Nobuyuki
Hishida, Asahi
Tanaka, Hideo
Watanabe, Yoshiyuki
Naito, Mariko
Suzuki, Sadao
Arisawa, Kokichi
Turin, Tanvir Chowdhury
Kawai, Sayo
Mikami, Haruo
Kubo, Michiaki
Wakai, Kenji
Kheradmand, Motahare
Tamura, Takashi
Imaizumi, Takeshi
Oze, Isao
Ohnaka, Keizo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease.
To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study.
The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay.
The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR < 60 ml/min/1.73 m2).
Participants with CKD accounted for 17.3% of the study population.
When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively.
There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD.
The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
American Psychological Association (APA)
Hishida, Asahi& Wakai, Kenji& Naito, Mariko& Tamura, Takashi& Kawai, Sayo& Hamajima, Nobuyuki…[et al.]. 2013. Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese : Cross-Sectional Data from the J-MICC Study. PPAR Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513198
Modern Language Association (MLA)
Hishida, Asahi…[et al.]. Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese : Cross-Sectional Data from the J-MICC Study. PPAR Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-513198
American Medical Association (AMA)
Hishida, Asahi& Wakai, Kenji& Naito, Mariko& Tamura, Takashi& Kawai, Sayo& Hamajima, Nobuyuki…[et al.]. Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese : Cross-Sectional Data from the J-MICC Study. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513198