ER81 Expression in Breast Cancers and Hyperplasia
Joint Authors
Chen, Yue
Li, BaoLin
Song, ShuLing
Yang, XuanTao
Yang, LiLin
Wang, Li
Wang, YuanYuan
Hao, Yan
Li, Lin
Yang, JuLun
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
ER81 is a transcription factor that may contribute to breast cancer; however, little known about the role of ER81 in breast carcinogenesis.
To investigate the role of ER81 in breast carcinogenesis, we examined ER81 expression in IDC, DCIS, ADH, HUT, and normal breast tissues by immunohistochemical staining.
We found that ER81 overexpression was detected in 25.7% (9/35) of HUT, 41.2% (7/17) of ADH, 54.5% (12/22) of DCIS, and 63.0% (51/81) of IDC.
In 20 of breast cancer tissues combined with DCIS, ADH, and HUT, ER81 expression was found in 14/20 (70%) IDC.
In these 14 cases all cases were ER81 positive expression in DCIS, 13 of 14 cases were positively expressed of ER81 in ADH and 8 of 14 were positive for ER81 in HUT components.
A statistical significance was found between NBT and HUT (P<.05) and HUT and ADH (P<.05).
Clinical-pathological features analysis of breast cancer revealed that ER81 expression was significantly associated with Her2 amplification and was negatively associated with ER and PR expression.
Our results demonstrated that ER81 overexpression was present in the early stage of breast development that suggested that ER81 overexpression may play an important role in breast carcinogenesis.
American Psychological Association (APA)
Wang, YuanYuan& Wang, Li& Chen, Yue& Li, Lin& Yang, XuanTao& Li, BaoLin…[et al.]. 2011. ER81 Expression in Breast Cancers and Hyperplasia. Pathology Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-513200
Modern Language Association (MLA)
Wang, YuanYuan…[et al.]. ER81 Expression in Breast Cancers and Hyperplasia. Pathology Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-513200
American Medical Association (AMA)
Wang, YuanYuan& Wang, Li& Chen, Yue& Li, Lin& Yang, XuanTao& Li, BaoLin…[et al.]. ER81 Expression in Breast Cancers and Hyperplasia. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-513200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513200