Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury
Joint Authors
Shih, Chia-Lin
Lee, Wen-Yuan
Lin, Tien-Jen
Lee, Fei-Peng
Tai, Yu-Ting
Chiu, Wen-Ta
Wang, Jia-Yi
Hung, Kuo-Sheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Traumatic brain injuries (TBIs) are a major health care problem worldwide.
Approximately 1.5 million new TBI cases occur annually in the United States, with mortality rates ranging between 35% and 40% in severe patients.
Despite the incidence of these injuries and their substantial socioeconomic implications, no specific pharmacological intervention is available for clinical use.
Several studies have indicated that 300 mg/kg or 400 mg/kg of valproate (VPA) exhibits neuroprotective effects in animal models.
However, humans cannot tolerate high doses of VPA.
This study aims to investigate whether 30 mg/kg of VPA administered to rats affects TBIs.
Methods.
We used a rat model to test the effects of 30 mg/kg of VPA on TBIs.
Molecular identifications for histone acetylation and phosphorylation of cAMP response element-binding protein (CREB) and phosphorylated extracellular signal regulated kinase (ERK) were performed.
Results.
The results indicated that treating adult rats with VPA after TBIs significantly decreased the contusion volume and recovery of contusion-related skilled forelimb reaching deficits.
Applying VPA also increased histone acetylation, p-ERK, and p-CREB expression in the brain.
Furthermore, applying VPA reduced inflammation, glial fibrillary acidic protein activation, and apoptosis.
Conclusion.
This study found that 30 mg/kg of VPA assists in treating TBIs in rat models.
American Psychological Association (APA)
Tai, Yu-Ting& Lee, Wen-Yuan& Lee, Fei-Peng& Lin, Tien-Jen& Shih, Chia-Lin& Wang, Jia-Yi…[et al.]. 2014. Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-513215
Modern Language Association (MLA)
Tai, Yu-Ting…[et al.]. Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-513215
American Medical Association (AMA)
Tai, Yu-Ting& Lee, Wen-Yuan& Lee, Fei-Peng& Lin, Tien-Jen& Shih, Chia-Lin& Wang, Jia-Yi…[et al.]. Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-513215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513215