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Reconstruction of Sugar Metabolic Pathways of Giardia lamblia
Joint Authors
Source
International Journal of Proteomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Giardia lamblia is an “important” pathogen of humans, but as a diplomonad excavate it is evolutionarily distant from other eukaryotes and relatively little is known about its core metabolic pathways.
KEGG, the widely referenced site for providing information of metabolism, does not yet include many enzymes from Giardia species.
Here we identify Giardia’s core sugar metabolism using standard bioinformatic approaches.
By comparing Giardia proteomes with known enzymes from other species, we have identified enzymes in the glycolysis pathway, as well as some enzymes involved in the TCA cycle and oxidative phosphorylation.
However, the majority of enzymes from the latter two pathways were not identifiable, indicating the likely absence of these functionalities.
We have also found enzymes from the Giardia glycolysis pathway that appear more similar to those from bacteria.
Because these enzymes are different from those found in mammals, the host organisms for Giardia, we raise the possibility that these bacteria-like enzymes could be novel drug targets for treating Giardia infections.
American Psychological Association (APA)
Han, Jian& Collins, Lesley J.. 2012. Reconstruction of Sugar Metabolic Pathways of Giardia lamblia. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513239
Modern Language Association (MLA)
Han, Jian& Collins, Lesley J.. Reconstruction of Sugar Metabolic Pathways of Giardia lamblia. International Journal of Proteomics No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513239
American Medical Association (AMA)
Han, Jian& Collins, Lesley J.. Reconstruction of Sugar Metabolic Pathways of Giardia lamblia. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513239