Use of Near-Infrared Spectroscopic Analysis of Second Trimester Amniotic Fluid to Assess Preterm Births
Joint Authors
Sanchez-Galan, Javier E.
Power, Kristin M.
Koski, Kristine G.
Burns, David H.
Luskey, Gary W.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This pilot study investigated the possibility that metabolomic differences exist in second trimester of women delivering at term (≥37 weeks, n=216) and preterm (≤35 weeks, n=11).
For this retrospective study, biobanked AF samples underwent near-infrared (NIR) spectral analysis using wavelengths from 700 to 1050 nm.
Spectral data was compressed then optimized by multilinear regression to create a calibration model.
The resultant model was able to classify term and preterm births based on differing AF metabolomic profiles with a sensitivity and specificity of 100%.
When groups were classified using a prematurity index (PI), there was a statistical difference (P<0.001) between the predicted preterm group (PI 0.77±0.08) and the term group (PI 1.00±0.02).
In conclusion, the 2nd trimester AF samples showed distinct differences in metabolomic profiles between patients delivering preterm as compared to those at term in functional groups related to proteins, carbohydrates, fats, polyols, and water.
American Psychological Association (APA)
Power, Kristin M.& Sanchez-Galan, Javier E.& Luskey, Gary W.& Koski, Kristine G.& Burns, David H.. 2011. Use of Near-Infrared Spectroscopic Analysis of Second Trimester Amniotic Fluid to Assess Preterm Births. Journal of Pregnancy،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-513262
Modern Language Association (MLA)
Power, Kristin M.…[et al.]. Use of Near-Infrared Spectroscopic Analysis of Second Trimester Amniotic Fluid to Assess Preterm Births. Journal of Pregnancy No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-513262
American Medical Association (AMA)
Power, Kristin M.& Sanchez-Galan, Javier E.& Luskey, Gary W.& Koski, Kristine G.& Burns, David H.. Use of Near-Infrared Spectroscopic Analysis of Second Trimester Amniotic Fluid to Assess Preterm Births. Journal of Pregnancy. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-513262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513262