CRT in Patients with Heart Failure : Time Course of Perfusion and Wall Motion Changes
Joint Authors
Marzullo, Paolo
Frumento, Paolo
Valle, Guido
Stanislao, Mario
Piacenti, Marcello
Startari, Umberto
Gimelli, Alessia
Source
Cardiology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In patients treated with CRT no data relative to the relationship between regional wall motion and perfusion and reverse remodelling of the left ventricle at short and medium term followup were available.
To this aim, 36 heart failure patients were studied by G-SPECT before (T0), within 2 months (T1) and 6 months (T2) after CRT.
A clinical followup was completed for 36 months.
In 30/36 patients there was an improvement of NYHA Class at T1 that persisted at T2.
G-SPECT showed significant improvement of perfusion at T1 in 92% of patients without further changes at T2.
A reduction of LV volumes, an increase of EF and an improvement of regional wall motion and thickening were observed at T1 versus baseline, with only minor changes at T2.
Moreover, baseline extension of perfusion defects was scarcely correlated with improvement after CRT.
Finally, end diastolic volume, perfusion defect and diabetes mellitus were independent predictors of survival.
The main effects of CRT on regional myocardial perfusion and wall motion are obtained within 2 months.
Volume overload modulates recovery of ventricular function independently of reperfusion and, with extension of perfusion abnormalities and diabetes were independent predictors of survival during followup.
American Psychological Association (APA)
Gimelli, Alessia& Frumento, Paolo& Valle, Guido& Stanislao, Mario& Startari, Umberto& Piacenti, Marcello…[et al.]. 2010. CRT in Patients with Heart Failure : Time Course of Perfusion and Wall Motion Changes. Cardiology Research and Practice،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-513266
Modern Language Association (MLA)
Gimelli, Alessia…[et al.]. CRT in Patients with Heart Failure : Time Course of Perfusion and Wall Motion Changes. Cardiology Research and Practice No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-513266
American Medical Association (AMA)
Gimelli, Alessia& Frumento, Paolo& Valle, Guido& Stanislao, Mario& Startari, Umberto& Piacenti, Marcello…[et al.]. CRT in Patients with Heart Failure : Time Course of Perfusion and Wall Motion Changes. Cardiology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-513266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513266