Adult Onset Still’s Disease : A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations

Abstract EN

Adult-onset Still’s disease is an inflammatory multisystemic disease of unknown etiology.

Pleuritis is the most common pulmonary manifestation and pleural effusions are usually exudates with a predominance of neutrophils.

We report a case of an eosinophilic pleural effusion as a novel and hitherto unrecognized manifestation of active adult-onset Still’s disease.

We also observed a marked NLRP3 inflammasome activation with increased production of IL-1β which coincided with the development and resolved upon remission of the pleural effusion suggesting a possible novel pathogenetic pathway for the development of pleural effusions in the context of the auto-inflammatory disorders.