Randomized, Double-Blind, and Placebo-Controlled Trial of Clenbuterol in Denervated Muscle Atrophy
Joint Authors
Zhang, Li-Yin
Xu, Jian-Guang
Yu, Cong
Shen, Li-Ying
Jiang, Guang-Liang
Gu, Yu-Dong
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Objectives.
β2-adrenergic agonists, such as clenbuterol, have been shown to promote the hypertrophy of healthy skeletal muscles and to ameliorate muscle wasting in a few pathological conditions in both animals and humans.
We intended to investigate the clinical efficacy of clenbuterol on attenuating denervation-induced muscle atrophy.
Methods.
A double-blind, placebo-controlled, parallel, and randomized trial was employed.
71 patients, suffering from brachial plexus injuries, were given either clenbuterol (60 μg, bid) or placebo for 3 months.
Before and at the end of the study, patients were given physical examinations, biopsies of biceps brachii, electromyograms (EMGs), and other laboratory tests.
Results.
Compared with placebo treatment, clenbuterol significantly mitigated the decreases in cross-sectional areas of type I and II muscle fibers and alleviated the reduction in fibrillation potential amplitudes, without any adverse effects.
Conclusions.
Clenbuterol safely ameliorated denervated muscle atrophy in this cohort; thus larger clinical studies are encouraged for this or other β2 agonists on denervation-induced muscle atrophy.
American Psychological Association (APA)
Jiang, Guang-Liang& Gu, Yu-Dong& Zhang, Li-Yin& Shen, Li-Ying& Yu, Cong& Xu, Jian-Guang. 2011. Randomized, Double-Blind, and Placebo-Controlled Trial of Clenbuterol in Denervated Muscle Atrophy. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513274
Modern Language Association (MLA)
Jiang, Guang-Liang…[et al.]. Randomized, Double-Blind, and Placebo-Controlled Trial of Clenbuterol in Denervated Muscle Atrophy. ISRN Pharmaceutics No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-513274
American Medical Association (AMA)
Jiang, Guang-Liang& Gu, Yu-Dong& Zhang, Li-Yin& Shen, Li-Ying& Yu, Cong& Xu, Jian-Guang. Randomized, Double-Blind, and Placebo-Controlled Trial of Clenbuterol in Denervated Muscle Atrophy. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513274