Stem Cell-Like Circulating Tumor Cells Indicate Poor Prognosis in Gastric Cancer
Joint Authors
Ji, Yinglan
Zhang, Baogang
Liu, Xia
Li, Man
Jiang, Yong
Luo, Dan
Zhai, Haoyu
Qi, Xiangjuan
Zhang, Zhiguang
Zhao, Jianqiu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Circulating tumor cells (CTCs), which have stem cell-like characteristics, might play a crucial role in cancer metastasis.
CD44 has been identified as gastric cancer (GC) stem cell (CSC) marker.
Here, the prognostic significance of CD44-positive CTCs in GC patients was investigated.
CTCs were detected in 27 of 45 GC patients.
The presence of CTCs was significantly associated with lymph node metastasis, distant metastasis, and recurrence (P=0.007, P=0.035, and P=0.035, resp.).
Nineteen of the 27 CTC-positive patients had CD44-positive CTCs.
These patients were more likely to develop metastasis and recurrence than patients with CD44-negative CTCs.
CD44-positive CTC counts were higher in recurrent patients than in the nonrecurrent ones (means 4.8 and 1.9, resp.; P=0.010).
Furthermore, 13 of 19 patients with CD44-positive CTCs developed recurrent disease, and the mean time to recurrence was shorter than that in patients with CD44-negative CTCs (10.54±5.55 and 19.13±9.72 months, resp.; P=0.04).
COX proportional hazards model indicated that the presence of CD44-positive CTCs and TNM stage were independent predictors of recurrence for GC (P=0.030 and 0.008).
So identifying the stem cell-like CTC subset may provide more clinically useful prognostic information than only detecting CTCs.
American Psychological Association (APA)
Li, Man& Zhang, Baogang& Zhang, Zhiguang& Liu, Xia& Qi, Xiangjuan& Zhao, Jianqiu…[et al.]. 2014. Stem Cell-Like Circulating Tumor Cells Indicate Poor Prognosis in Gastric Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513275
Modern Language Association (MLA)
Li, Man…[et al.]. Stem Cell-Like Circulating Tumor Cells Indicate Poor Prognosis in Gastric Cancer. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-513275
American Medical Association (AMA)
Li, Man& Zhang, Baogang& Zhang, Zhiguang& Liu, Xia& Qi, Xiangjuan& Zhao, Jianqiu…[et al.]. Stem Cell-Like Circulating Tumor Cells Indicate Poor Prognosis in Gastric Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513275