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FGF21 as an Endocrine Regulator in Lipid Metabolism : From Molecular Evolution to Physiology and Pathophysiology
Joint Authors
Itoh, Nobuyuki
Murata, Yusuke
Konishi, Morichika
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The FGF family comprises twenty-two structurally related proteins with functions in development and metabolism.
The Fgf21 gene was generated early in vertebrate evolution.
FGF21 acts as an endocrine regulator in lipid metabolism.
Hepatic Fgf21 expression is markedly induced in mice by fasting or a ketogenic diet.
Experiments with Fgf21 transgenic mice and cultured cells indicate that FGF21 exerts pharmacological effects on glucose and lipid metabolism in hepatocytes and adipocytes via cell surface FGF receptors.
However, experiments with Fgf21 knockout mice indicate that FGF21 inhibits lipolysis in adipocytes during fasting and attenuates torpor induced by a ketogenic diet but maybe not a physiological regulator for these hepatic functions.
These findings suggest the pharmacological effects to be distinct from the physiological roles.
Serum FGF21 levels are increased in patients with metabolic diseases having insulin resistance, indicating that FGF21 is a metabolic regulator and a biomarker for these diseases.
American Psychological Association (APA)
Murata, Yusuke& Konishi, Morichika& Itoh, Nobuyuki. 2011. FGF21 as an Endocrine Regulator in Lipid Metabolism : From Molecular Evolution to Physiology and Pathophysiology. Journal of Nutrition and Metabolism،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513285
Modern Language Association (MLA)
Murata, Yusuke…[et al.]. FGF21 as an Endocrine Regulator in Lipid Metabolism : From Molecular Evolution to Physiology and Pathophysiology. Journal of Nutrition and Metabolism No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-513285
American Medical Association (AMA)
Murata, Yusuke& Konishi, Morichika& Itoh, Nobuyuki. FGF21 as an Endocrine Regulator in Lipid Metabolism : From Molecular Evolution to Physiology and Pathophysiology. Journal of Nutrition and Metabolism. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513285