A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis
Joint Authors
McCallan, Lyanne
Thompson, Suzan
McNair, Jim
Aagaard, Claus
McMurray, David N.
Strain, Samuel
Corbett, David
Andersen, Peter L.
Barry, Claire
Source
Veterinary Medicine International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is significant interest in developing vaccines to control bovine tuberculosis, especially in wildlife species where this disease continues to persist in reservoir species such as the European Badger (Meles meles).
However, gaining access to populations of badgers (protected under UK law) is problematic and not always possible.
In this study, a new infection model has been developed in ferrets (Mustela furo), a species which is closely related to the badger.
Groups of ferrets were infected using a Madison infection chamber and were examined postmortem for the presence of tuberculous lesions and to provide tissue samples for confirmation of Mycobacterium bovis by culture.
An infectious dose was defined, that establishes infection within the lungs and associated lymph nodes with subsequent spread to the mesentery lymph nodes.
This model, which emphasises respiratory tract infection, will be used to evaluate vaccines for the control of bovine tuberculosis in wildlife species.
American Psychological Association (APA)
McCallan, Lyanne& Corbett, David& Andersen, Peter L.& Aagaard, Claus& McMurray, David N.& Barry, Claire…[et al.]. 2011. A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis. Veterinary Medicine International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-513295
Modern Language Association (MLA)
McCallan, Lyanne…[et al.]. A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis. Veterinary Medicine International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-513295
American Medical Association (AMA)
McCallan, Lyanne& Corbett, David& Andersen, Peter L.& Aagaard, Claus& McMurray, David N.& Barry, Claire…[et al.]. A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis. Veterinary Medicine International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-513295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513295