Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats
Joint Authors
Mahmoud, Marwa M.
Rifaai, Rehab A.
Morsy, Mohamed A.
El-Sheikh, Azza A. K.
Abdelrahman, Aly M.
Source
Advances in Pharmacological Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic.
Here, we investigated possible protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and the mechanisms involved.
Two doses (10 and 100 mg/kg) of CoQ10 were administered orally to rats for 8 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of Dox (15 mg/kg) at day 4 of the experiment.
Our results showed that the low dose of CoQ10 succeeded in reversing Dox-induced nephrotoxicity to control levels (e.g., levels of blood urea nitrogen and serum creatinine, concentrations of renal reduced glutathione (GSH) and malondialdehyde, catalase activity and caspase 3 expression, and renal histopathology).
Alternatively, the high dose of CoQ10 showed no superior nephroprotection over the low dose, as there were no significant improvements in renal histopathology, catalase activity, or caspase 3 expression compared to the Dox-treated group.
Interestingly, the high dose of CoQ10 alone significantly decreased renal GSH level as well as catalase activity and caused a mild induction of caspase 3 expression compared to control, probably due to a prooxidant effect at this dose of CoQ10.
We conclude that CoQ10 protects from Dox-induced nephrotoxicity with a precaution to dosage adjustment.
American Psychological Association (APA)
El-Sheikh, Azza A. K.& Morsy, Mohamed A.& Mahmoud, Marwa M.& Rifaai, Rehab A.& Abdelrahman, Aly M.. 2012. Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats. Advances in Pharmacological Sciences،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-513298
Modern Language Association (MLA)
El-Sheikh, Azza A. K.…[et al.]. Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats. Advances in Pharmacological Sciences No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-513298
American Medical Association (AMA)
El-Sheikh, Azza A. K.& Morsy, Mohamed A.& Mahmoud, Marwa M.& Rifaai, Rehab A.& Abdelrahman, Aly M.. Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats. Advances in Pharmacological Sciences. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-513298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513298