Regulation of HuR by DNA Damage Response Kinases
Joint Authors
Abdelmohsen, Kotb
Gorospe, Myriam
Kim, Hyeon Ho
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
As many DNA-damaging conditions repress transcription, posttranscriptional processes critically influence gene expression during the genotoxic stress response.
The RNA-binding protein HuR robustly influences gene expression following DNA damage.
HuR function is controlled in two principal ways: (1) by mobilizing HuR from the nucleus to the cytoplasm, where it modulates the stability and translation of target mRNAs and (2) by altering its association with target mRNAs.
Here, we review evidence that two main effectors of ataxia-telangiectasia-mutated/ATM- and Rad3-related (ATM/ATR), the checkpoint kinases Chk1 and Chk2, jointly influence HuR function.
Chk1 affects HuR localization by phosphorylating (hence inactivating) Cdk1, a kinase that phosphorylates HuR and thereby blocks HuR's cytoplasmic export.
Chk2 modulates HuR binding to target mRNAs by phosphorylating HuR's RNA-recognition motifs (RRM1 and RRM2).
We discuss how HuR phosphorylation by kinases including Chk1/Cdk1 and Chk2 impacts upon gene expression patterns, cell proliferation, and survival following genotoxic injury.
American Psychological Association (APA)
Kim, Hyeon Ho& Abdelmohsen, Kotb& Gorospe, Myriam. 2010. Regulation of HuR by DNA Damage Response Kinases. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-513304
Modern Language Association (MLA)
Kim, Hyeon Ho…[et al.]. Regulation of HuR by DNA Damage Response Kinases. Journal of Nucleic Acids No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-513304
American Medical Association (AMA)
Kim, Hyeon Ho& Abdelmohsen, Kotb& Gorospe, Myriam. Regulation of HuR by DNA Damage Response Kinases. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-513304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513304