Treatment of Deep Vein Thrombosis with Continuous IV Infusion of LMWH : A Retrospective Study in 32 Children

Abstract EN

Thirty-two consecutive children aged 0–18 years with VTE treated with LMWH administered as a continuous infusion (CI) were identified at the Children's University Hospital Brno.

The treatment led to at least partial resolution of the thrombus within two weeks in 85% of patients.

There were no adverse events or increased bleeding reported in any patients.

No recurrences were observed during a followup period of 6 months.

Although continuous infusion should not replace subcutaneous (SC) administration of LMWH, CI appeared to be safe and efficient and may provide an alternate method of administering LMWH in a subset of the paediatric population where SC administration may not be feasible.

Further prospective studies are needed to support the promising findings of our pilot clinical observation.