Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment : Opportunities and Challenges
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Clostridium perfringens enterotoxin (CPE) causes the symptoms associated with several common gastrointestinal diseases.
CPE is a 35 kDa polypeptide consisting of three structured domains, that is, C-terminal domain I (responsible for receptor binding), domain II (responsible for oligomerization and membrane insertion), and domain III (which may participate in physical changes when the CPE protein inserts into membranes).
Native CPE binds to claudin receptors, which are components of the tight junction.
The bound toxin then assembles into a hexameric prepore on the membrane surface, prior to the insertion of this oligomer into membranes to form an active pore.
The toxin is especially lethal for cells expressing large amounts of claudin-3 or -4, which includes many cancer cells.
Initial studies suggest that native CPE has potential usefulness for treating several cancers where claudin CPE receptors are overexpressed.
However, some challenges with immunogenicity, toxicity, and (possibly) the development of resistance may need to be overcome.
An alternative approach now being explored is to utilize C-CPE, which corresponds approximately to receptor binding domain I, to enhance paracellular permeability and delivery of chemotherapeutic agents against cancer cells.
Alternatively, C-CPE fusion proteins may prove superior to use of native CPE for cancer treatment.
Finally, C-CPE may have application for other medical treatments, including vaccination or increasing drug absorption.
The coming years should witness increasing exploitation of this otherwise formidable toxin.
American Psychological Association (APA)
Gao, Zhijian& McClane, Bruce A.. 2011. Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment : Opportunities and Challenges. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513320
Modern Language Association (MLA)
Gao, Zhijian& McClane, Bruce A.. Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment : Opportunities and Challenges. Journal of Toxicology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513320
American Medical Association (AMA)
Gao, Zhijian& McClane, Bruce A.. Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment : Opportunities and Challenges. Journal of Toxicology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513320