Expression of LacdiNAc Groups on N-Glycans among Human Tumors Is Complex
Joint Authors
Hirano, Kiyoko
Matsuda, Akio
Shirai, Takashi
Furukawa, Kiyoshi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aberrant glycosylation of proteins and lipids is one of the characteristic features of malignantly transformed cells.
The GalNAcβ1 → 4GlcNAc (LacdiNAc or LDN) group at the nonreducing termini of both N- and O-glycans is not generally found in mammalian cells.
We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.
In contrast, the enhanced expression of the LacdiNAc group has been shown to be associated with the progression of human prostate, ovarian, and pancreatic cancers.
Therefore, the expression of the disaccharide group appears to be dependent on types of tumors.
The mechanism of formation of the LacdiNAc group in human tumors and cancer cells has been studied, and two β4-N-acetylgalacto-saminyltransferases (β4GalNAcTs), β4GalNAcT3 and β4GalNAcT4, have been shown to be involved in the biosynthesis of this disaccharide group in a tissue-dependent manner.
Transfection of the β4GalNAcT3 gene brought about significant changes in the malignant phenotypes of human neuroblastoma, indicating that this disaccharide group is important for suppressing the tumor growth.
American Psychological Association (APA)
Hirano, Kiyoko& Matsuda, Akio& Shirai, Takashi& Furukawa, Kiyoshi. 2014. Expression of LacdiNAc Groups on N-Glycans among Human Tumors Is Complex. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513321
Modern Language Association (MLA)
Hirano, Kiyoko…[et al.]. Expression of LacdiNAc Groups on N-Glycans among Human Tumors Is Complex. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-513321
American Medical Association (AMA)
Hirano, Kiyoko& Matsuda, Akio& Shirai, Takashi& Furukawa, Kiyoshi. Expression of LacdiNAc Groups on N-Glycans among Human Tumors Is Complex. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513321