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The Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism
Joint Authors
Milewski, Robert
Popławska-Kita, Anna
Myśliwiec, Janusz
Modzelewska, Anna
Szelachowska, Małgorzata
Górska, Maria
Telejko, Beata
Siewko, Katarzyna
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
The aim of the present study was to compare the levels of circulating markers of endothelial function and low-grade inflammation in patients with subclinical and overt hyperthyroidism (OH) due to Graves disease (GD) and toxic nodular goiter (TNG).
Material and Methods.
The group studied consisted of 42 patients with GD, 75 patients with TNG, and 39 healthy controls.
Results.
Circulating markers of endothelial dysfunction were elevated in the patients with both SH and OH, but the concentrations of interleukin-12 (IL-12) (P<0.05), IL-18 (P<0.05), fibrinogen (P<0.01), and von Willebrand factor (vWF) (P<0.05) were significantly higher in the OH than in the SH group.
The highest levels of IL-6, IL-12, IL-18, vWF, sVCAM-1, and fibrinogen were found in the patients with GD, but the differences between the GD, and TNG groups were not significant.
In the subjects with OH serum IL-6 was positively associated with FT3 (R=0.276, P<0.05), FT4 (R=0.273, P<0.05), and thyroid peroxidase antibodies (R=0.346, P<0.01) levels.
Conclusion.
Our results may suggest that both SH and OH may be associated with endothelial dysfunction, which is reflected by decreased fibrinolytic activity, hypercoagulability, and increased levels of IL-6, IL-12, and IL-18 and depends not only on the cause but also on the degree of hyperthyroidism.
American Psychological Association (APA)
Popławska-Kita, Anna& Siewko, Katarzyna& Telejko, Beata& Modzelewska, Anna& Myśliwiec, Janusz& Milewski, Robert…[et al.]. 2013. The Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-513322
Modern Language Association (MLA)
Popławska-Kita, Anna…[et al.]. The Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-513322
American Medical Association (AMA)
Popławska-Kita, Anna& Siewko, Katarzyna& Telejko, Beata& Modzelewska, Anna& Myśliwiec, Janusz& Milewski, Robert…[et al.]. The Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-513322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513322