Identification of C-Kit-Positive Interstitial Cells in the Dog Lower Urinary Tract and Relationship with Smooth Muscle and Nerves. Hypotheses for a Likely Pacemaker Role.
Joint Authors
Groppetti, Debora
Cremonesi, Fausto
Arrighi, Silvana
Bosi, Giampaolo
Source
Veterinary Medicine International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this work was to give an evidence of the likely presence of interstitial cells in the canine lower urinary tract and to study their possible interactions with the musculature and the intramural innervation.
Cryosections of normal canine bladder and urethra were immunofluorescently labelled with c-kit, a transmembrane, tyrosine kinase growth factor receptor, known to be expressed on the interstitial cells of Cajal (ICCs) of the gut.
The relationship with antiactin positive smooth muscle cells and PGP9.5-positive intramural innervation was also investigated by confocal microscopy.
Anti-c-kit labelling demonstrated a network of elongated and branched c-kit positive cells, which were located in interstitial spaces, oriented in parallel to the smooth muscle bundles that form the bladder muscular layer, irrespective of dog sex.
Cells with a similar localization were also PAS- and NADPH-diaphorase-positive.
A contact between c-kit immunofluorescent cells and intramural innervation was demonstrated, too.
The roles of interstitial cells might include regulation of smooth muscle activity of the bladder detrusor, integrating neuronal signals during urine storage and voiding.
American Psychological Association (APA)
Arrighi, Silvana& Bosi, Giampaolo& Groppetti, Debora& Cremonesi, Fausto. 2010. Identification of C-Kit-Positive Interstitial Cells in the Dog Lower Urinary Tract and Relationship with Smooth Muscle and Nerves. Hypotheses for a Likely Pacemaker Role.. Veterinary Medicine International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-513330
Modern Language Association (MLA)
Arrighi, Silvana…[et al.]. Identification of C-Kit-Positive Interstitial Cells in the Dog Lower Urinary Tract and Relationship with Smooth Muscle and Nerves. Hypotheses for a Likely Pacemaker Role.. Veterinary Medicine International No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-513330
American Medical Association (AMA)
Arrighi, Silvana& Bosi, Giampaolo& Groppetti, Debora& Cremonesi, Fausto. Identification of C-Kit-Positive Interstitial Cells in the Dog Lower Urinary Tract and Relationship with Smooth Muscle and Nerves. Hypotheses for a Likely Pacemaker Role.. Veterinary Medicine International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-513330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513330