Decreased Apoptotic Rate of Alveolar Macrophages of Patients with Idiopathic Pulmonary Fibrosis
Joint Authors
Bouros, Demosthenes
Drakopanagiotakis, Fotios
Tsakanika, Konstantina
Karameris, Andreas
Karagiannidis, Napoleon
Mermigkis, Demetrios
Xifteri, Areti
Tsiambas, Evaggelos
Polychronopoulos, Vlasis
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Increased apoptosis of epithelial cells and decreased apoptosis of myofibroblasts are involved in the pathogenesis of IPF.
The apoptotic profile of alveolar macrophages (AMs) in IPF is unclear.
Aim.
To investigate whether AMs of patients with IPF exhibit a different apoptotic profile compared to normal subjects.
Methods.
We analyzed, by immunohistochemistry, the expression of the apoptotic markers fas, fas ligand , bcl-2, and bax in AM obtained from bronchoalveolar lavage fluid (BALF) of 20 newly diagnosed, treatment-naive IPF patients and of 16 controls.
Apoptosis of AM was evaluated by Apoptag immunohistochemistry.
IPF patients received either interferon-g and corticosteroids or azathioprine and corticosteroids for six months.
Results.
BALF AMs undergoing apoptosis were significantly less in IPF patients.
No difference was found in the expression of fas or fas ligand, bcl-2 and bax between IPF and control group.
No difference was found between the respiratory function parameters of the two treatment groups after six months.
A positive correlation was found between the number of bcl-2 positive stained macrophages and DLCO after treatment.
Conclusions.
The decreased apoptotic rate of AM of patients with IPF is not associated with decreased expression of apoptosis mediators involved in the external or internal apoptotic pathway.
American Psychological Association (APA)
Drakopanagiotakis, Fotios& Xifteri, Areti& Tsiambas, Evaggelos& Karameris, Andreas& Tsakanika, Konstantina& Karagiannidis, Napoleon…[et al.]. 2012. Decreased Apoptotic Rate of Alveolar Macrophages of Patients with Idiopathic Pulmonary Fibrosis. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513336
Modern Language Association (MLA)
Drakopanagiotakis, Fotios…[et al.]. Decreased Apoptotic Rate of Alveolar Macrophages of Patients with Idiopathic Pulmonary Fibrosis. Pulmonary Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513336
American Medical Association (AMA)
Drakopanagiotakis, Fotios& Xifteri, Areti& Tsiambas, Evaggelos& Karameris, Andreas& Tsakanika, Konstantina& Karagiannidis, Napoleon…[et al.]. Decreased Apoptotic Rate of Alveolar Macrophages of Patients with Idiopathic Pulmonary Fibrosis. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513336