Curcumin Decreased Oxidative Stress, Inhibited NF-κB Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats
Joint Authors
Thong-Ngam, Duangporn
Klaikeaw, Naruemon
Suyasunanont, Doungsamon
Kulaputana, Onanong
Samuhasaneeto, Suchittra
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To study the mechanism of curcumin-attenuated inflammation and liver pathology in early stage of alcoholic liver disease, female Sprague-Dawley rats were divided into four groups and treated with ethanol or curcumin via an intragastric tube for 4 weeks.
A control group treated with distilled water, and an ethanol group was treated with ethanol (7.5 g/kg bw).
Treatment groups were fed with ethanol supplemented with curcumin (400 or 1 200 mg/kg bw).
The liver histopathology in ethanol group revealed mild-to-moderate steatosis and mild necroinflammation.
Hepatic MDA, hepatocyte apoptosis, and NF-κB activation increased significantly in ethanol-treated group when compared with control.
Curcumin treatments resulted in improving of liver pathology, decreasing the elevation of hepatic MDA, and inhibition of NF-κB activation.
The 400 mg/kg bw of curcumin treatment revealed only a trend of decreased hepatocyte apoptosis.
However, the results of SOD activity, PPARγ protein expression showed no difference among the groups.
In conclusion, curcumin improved liver histopathology in early stage of ethanol-induced liver injury by reduction of oxidative stress and inhibition of NF-κB activation.
American Psychological Association (APA)
Samuhasaneeto, Suchittra& Thong-Ngam, Duangporn& Kulaputana, Onanong& Suyasunanont, Doungsamon& Klaikeaw, Naruemon. 2009. Curcumin Decreased Oxidative Stress, Inhibited NF-κB Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-513354
Modern Language Association (MLA)
Samuhasaneeto, Suchittra…[et al.]. Curcumin Decreased Oxidative Stress, Inhibited NF-κB Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-513354
American Medical Association (AMA)
Samuhasaneeto, Suchittra& Thong-Ngam, Duangporn& Kulaputana, Onanong& Suyasunanont, Doungsamon& Klaikeaw, Naruemon. Curcumin Decreased Oxidative Stress, Inhibited NF-κB Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-513354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513354