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Bone Marrow Plasma Cell Assessment before Peripheral Blood Stem Cell Mobilization in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation
Joint Authors
Lee, Jong Wook
Shin, Seung-Hwan
Eom, Ki-Seong
Lee, Seok
Kim, Hee-Je
Lee, Sung-Eun
Cho, Seok-Goo
Park, Chong-Won
Min, Woo-Sung
Kim, Myungshin
Min, Chang-Ki
Yoon, Jae-Ho
Kim, Yoo-Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The current definition of complete response (CR) in multiple myeloma (MM) includes negative serum and urine immunofixation (IFE) tests and <5% bone marrow plasma cells (BMPCs).
However, many studies of the prognostic impact of pretransplant response have not included BMPCs.
We evaluated the prognostic impact of BMPC assessment before peripheral blood stem cell (PBSC) mobilization on subsequent transplant outcomes.
BMPCs were assessed by CD138, kappa, and lambda immunostaining in 106 patients.
After a median followup of 24.5 months, patients with <5% BMPCs had a significantly better progression-free survival (PFS) compared to those with ≥5% BMPCs (P=0.005).
Patients with <5% BMPCs + serologic CR showed superior PFS compared to those with <5% BMPCs + serologic non-CR (P=0.050) or ≥5% BMPCs + serologic non-CR (P=0.001).
Interestingly, the prognostic impact of BMPCs was more apparent for patients who did not achieve a serologic CR (P=0.042) compared to those with a serologic CR (P=0.647).
We concluded that IFE negativity and <5% BMPCs before PBSC mobilization were important factors to predict PFS in patients with MM undergoing ASCT.
Particularly, a significant impact of <5% BMPCs was observed in patients who did not achieve IFE negativity.
American Psychological Association (APA)
Lee, Sung-Eun& Yoon, Jae-Ho& Shin, Seung-Hwan& Eom, Ki-Seong& Kim, Yoo-Jin& Kim, Hee-Je…[et al.]. 2014. Bone Marrow Plasma Cell Assessment before Peripheral Blood Stem Cell Mobilization in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-513400
Modern Language Association (MLA)
Lee, Sung-Eun…[et al.]. Bone Marrow Plasma Cell Assessment before Peripheral Blood Stem Cell Mobilization in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-513400
American Medical Association (AMA)
Lee, Sung-Eun& Yoon, Jae-Ho& Shin, Seung-Hwan& Eom, Ki-Seong& Kim, Yoo-Jin& Kim, Hee-Je…[et al.]. Bone Marrow Plasma Cell Assessment before Peripheral Blood Stem Cell Mobilization in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-513400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513400