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Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats
Joint Authors
Yao, Hsien-Tsung
Chiang, Jia-Rong
Chen, Chiung-Tong
Lii, Chong-Kuei
Huang, Chin-Shiu
Li, Chien-Chun
Liu, Cheng-Tzu
Liu, Pei-Fen
Chen, Haw-Wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Andrographolide is the most abundant terpenoid of A.
paniculata which is used in the treatment of diabetes.
In this study, we investigated the effects of A.
paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes in rat liver and determined whether modulation of these enzymes changed the pharmacokinetics of tolbutamide.
Rats were intragastrically dosed with 2 g/kg/day APE or 50 mg/kg/day andrographolide for 5 days before a dose of 20 mg/kg tolbutamide was given.
APE and andrographolide reduced the AUC0–12 h of tolbutamide by 37% and 18%, respectively, compared with that in controls.
The protein and mRNA levels and enzyme activities of CYP2C6/11, CYP1A1/2, and CYP3A1/2 were increased by APE and andrographolide.
To evaluate whether APE or andrographolide affected the hypoglycemic action of tolbutamide, high-fat diet-induced obese mice were used and treated in the same manner as the rats.
APE and andrographolide increased CYP2C6/11 expression and decreased plasma tolbutamide levels.
In a glucose tolerance test, however, the hypoglycemic effect of tolbutamide was not changed by APE or andrographolide.
These results suggest that APE and andrographolide accelerate the metabolism rate of tolbutamide through increased expression and activity of drug-metabolizing enzymes.
APE and andrographolide, however, do not impair the hypoglycemic effect of tolbutamide.
American Psychological Association (APA)
Chen, Haw-Wen& Huang, Chin-Shiu& Liu, Pei-Fen& Li, Chien-Chun& Chen, Chiung-Tong& Liu, Cheng-Tzu…[et al.]. 2013. Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-513417
Modern Language Association (MLA)
Chen, Haw-Wen…[et al.]. Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-513417
American Medical Association (AMA)
Chen, Haw-Wen& Huang, Chin-Shiu& Liu, Pei-Fen& Li, Chien-Chun& Chen, Chiung-Tong& Liu, Cheng-Tzu…[et al.]. Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-513417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513417