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Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3
Joint Authors
Hatt, Hanns
Sherkheli, Muhammad Azhar
Gisselmann, Guenter
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Transient receptor potential vanilloid subtype 3 (TRPV3) is a thermosensitive ion channel expressed in a variety of neural cells and in keratinocytes.
It is activated by warmth (33–39°C), and its responsiveness is dramatically increased at nociceptive temperatures greater than 40°C.
Monoterpenoids and 2-APB are chemical activators of TRPV3 channels.
We found that Icilin, a known cooling substance and putative ligand of TRPM8, reversibly inhibits TRPV3 activity at nanomolar concentrations in expression systems like Xenopus laeves oocytes, HEK-293 cells, and in cultured human keratinocytes.
Our data show that icilin's antagonistic effects for the warm-sensitive TRPV3 ion channel occurs at very low concentrations.
Therefore, the cooling effect evoked by icilin may at least in part be due to TRPV3 inhibition in addition to TRPM8 potentiation.
Blockade of TRPV3 activity by icilin at such low concentrations might have important implications for overall cooling sensations detected by keratinocytes and free nerve endings in skin.
We hypothesize that blockage of TRPV3 might be a signal for cool-sensing systems (like TRPM8) to beat up the basal activity resulting in increased cold perception when warmth sensors (like TRPV3) are shut off.
American Psychological Association (APA)
Sherkheli, Muhammad Azhar& Gisselmann, Guenter& Hatt, Hanns. 2012. Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-513421
Modern Language Association (MLA)
Sherkheli, Muhammad Azhar…[et al.]. Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-513421
American Medical Association (AMA)
Sherkheli, Muhammad Azhar& Gisselmann, Guenter& Hatt, Hanns. Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-513421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513421