Receptor-Tyrosine-Kinase-Targeted Therapies for Head and Neck Cancer

Joint Authors

Resto, Vicente A.
Elferink, Lisa A.

Source

Journal of Signal Transduction

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-06-07

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology

Abstract EN

Molecular therapeutics for treating epidermal growth factor receptor-(EGFR-) expressing cancers are a specific method for treating cancers compared to general cell loss with standard cytotoxic therapeutics.

However, the finding that resistance to such therapy is common in clinical trials now dampens the initial enthusiasm over this targeted treatment.

Yet an improved molecular understanding of other receptor tyrosine kinases known to be active in cancer has revealed a rich network of cross-talk between receptor pathways with a key finding of common downstream signaling pathways.

Such cross talk may represent a key mechanism for resistance to EGFR-directed therapy.

Here we review the interplay between EGFR and Met and the type 1 insulin-like growth factor receptor (IGF-1R) tyrosine kinases, as well as their contribution to anti-EGFR therapeutic resistance in the context of squamous cell cancer of the head and neck, a tumor known to be primarily driven by EGFR-related oncogenic signals.

American Psychological Association (APA)

Elferink, Lisa A.& Resto, Vicente A.. 2011. Receptor-Tyrosine-Kinase-Targeted Therapies for Head and Neck Cancer. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-513436

Modern Language Association (MLA)

Elferink, Lisa A.& Resto, Vicente A.. Receptor-Tyrosine-Kinase-Targeted Therapies for Head and Neck Cancer. Journal of Signal Transduction No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-513436

American Medical Association (AMA)

Elferink, Lisa A.& Resto, Vicente A.. Receptor-Tyrosine-Kinase-Targeted Therapies for Head and Neck Cancer. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-513436

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-513436