Chemopreventive Potential of Synergy1 and Soybean in Reducing Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats
Joint Authors
Boateng, J.
Bhat, K. N
Verghese, M.
Gourineni, V. P.
Shackelford, L.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Synergy1, a prebiotic composed of Inulin and Oligofructose (1 : 1).
Soybean meal is a natural source of isoflavones.
The objective was to investigate the effects of feeding Synergy1 and SM on the incidence of azoxymethane- (AOM-) induced aberrant crypt foci (ACF) in Fisher 344 male rats.
Rats (54) were randomly assigned to 9 groups (n=6).
Control group (C) was fed AIN-93G and treatment groups Syn1 and SM at 5% and 10% singly and in combinations.
Rats were injected with two s/c injections of AOM at 7 and 8 weeks of age at 16 mg/kg body weight and killed at 17 weeks by CO2 asphyxiation.
Colonic ACF enumeration and hepatic enzyme activities were measured.
Reductions (%) in total ACF among treatment groups fed combinations were higher (67–77) compared to groups fed singly (52–64).
Synergistic mechanisms among phytochemicals may be responsible suggesting protective role in colon carcinogenesis with implications in food product development.
American Psychological Association (APA)
Gourineni, V. P.& Verghese, M.& Boateng, J.& Shackelford, L.& Bhat, K. N. 2011. Chemopreventive Potential of Synergy1 and Soybean in Reducing Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats. Journal of Nutrition and Metabolism،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513445
Modern Language Association (MLA)
Gourineni, V. P.…[et al.]. Chemopreventive Potential of Synergy1 and Soybean in Reducing Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats. Journal of Nutrition and Metabolism No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-513445
American Medical Association (AMA)
Gourineni, V. P.& Verghese, M.& Boateng, J.& Shackelford, L.& Bhat, K. N. Chemopreventive Potential of Synergy1 and Soybean in Reducing Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats. Journal of Nutrition and Metabolism. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513445