Cellular Kinetics of Perivascular MSC Precursors
Joint Authors
Zimmerlin, Ludovic
Park, Tea Soon
Chen, William C. W.
Huard, Johnny
Peault, Bruno
Murray, Iain R.
Lazzari, Lorenza
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Mesenchymal stem/stromal cells (MSCs) and MSC-like multipotent stem/progenitor cells have been widely investigated for regenerative medicine and deemed promising in clinical applications.
In order to further improve MSC-based stem cell therapeutics, it is important to understand the cellular kinetics and functional roles of MSCs in the dynamic regenerative processes.
However, due to the heterogeneous nature of typical MSC cultures, their native identity and anatomical localization in the body have remained unclear, making it difficult to decipher the existence of distinct cell subsets within the MSC entity.
Recent studies have shown that several blood-vessel-derived precursor cell populations, purified by flow cytometry from multiple human organs, give rise to bona fide MSCs, suggesting that the vasculature serves as a systemic reservoir of MSC-like stem/progenitor cells.
Using individually purified MSC-like precursor cell subsets, we and other researchers have been able to investigate the differential phenotypes and regenerative capacities of these contributing cellular constituents in the MSC pool.
In this review, we will discuss the identification and characterization of perivascular MSC precursors, including pericytes and adventitial cells, and focus on their cellular kinetics: cell adhesion, migration, engraftment, homing, and intercellular cross-talk during tissue repair and regeneration.
American Psychological Association (APA)
Chen, William C. W.& Park, Tea Soon& Murray, Iain R.& Zimmerlin, Ludovic& Lazzari, Lorenza& Huard, Johnny…[et al.]. 2013. Cellular Kinetics of Perivascular MSC Precursors. Stem Cells International،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-513451
Modern Language Association (MLA)
Chen, William C. W.…[et al.]. Cellular Kinetics of Perivascular MSC Precursors. Stem Cells International No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-513451
American Medical Association (AMA)
Chen, William C. W.& Park, Tea Soon& Murray, Iain R.& Zimmerlin, Ludovic& Lazzari, Lorenza& Huard, Johnny…[et al.]. Cellular Kinetics of Perivascular MSC Precursors. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-513451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513451