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Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy
Joint Authors
Zorec, Robert
Kreft, Marko
Calejo, Ana I.
Jorgačevski, Jernej
Kabaso, Doron
Iglič, Aleš
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The fusion pore is an aqueous channel that is formed upon the fusion of the vesicle membrane with the plasma membrane.
Once the pore is open, it may close again (transient fusion) or widen completely (full fusion) to permit vesicle cargo discharge.
While repetitive transient fusion pore openings of the vesicle with the plasma membrane have been observed in the absence of stimulation, their frequency can be further increased using a cAMP-increasing agent that drives the opening of nonspecific cation channels.
Our model hypothesis is that the openings and closings of the fusion pore are driven by changes in the local concentration of cations in the connected vesicle.
The proposed mechanism of fusion pore dynamics is considered as follows: when the fusion pore is closed or is extremely narrow, the accumulation of cations in the vesicle (increased cation concentration) likely leads to lipid demixing at the fusion pore.
This process may affect local membrane anisotropy, which reduces the spontaneous curvature and thus leads to the opening of the fusion pore.
Based on the theory of membrane elasticity, we used a continuum model to explain the rhythmic opening and closing of the fusion pore.Erratum to “Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy”dx.doi.org/10.1100/2012/193403
American Psychological Association (APA)
Kabaso, Doron& Calejo, Ana I.& Jorgačevski, Jernej& Kreft, Marko& Zorec, Robert& Iglič, Aleš. 2012. Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-513462
Modern Language Association (MLA)
Kabaso, Doron…[et al.]. Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-513462
American Medical Association (AMA)
Kabaso, Doron& Calejo, Ana I.& Jorgačevski, Jernej& Kreft, Marko& Zorec, Robert& Iglič, Aleš. Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-513462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513462