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Chelators in the Treatment of Iron Accumulation in Parkinson's Disease
Joint Authors
Teismann, Peter
Mounsey, Ross B.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Iron is an essential element in the metabolism of all cells.
Elevated levels of the metal have been found in the brains of patients of numerous neurodegenerative disorders, including Parkinson's disease (PD).
The pathogenesis of PD is largely unknown, although it is thought through studies with experimental models that oxidative stress and dysfunction of brain iron homeostasis, usually a tightly regulated process, play significant roles in the death of dopaminergic neurons.
Accumulation of iron is present at affected neurons and associated microglia in the substantia nigra of PD patients.
This additional free-iron has the capacity to generate reactive oxygen species, promote the aggregation of α-synuclein protein, and exacerbate or even cause neurodegeneration.
There are various treatments aimed at reversing this pathologic increase in iron content, comprising both synthetic and natural iron chelators.
These include established drugs, which have been used to treat other disorders related to iron accumulation.
This paper will discuss how iron dysregulation occurs and the link between increased iron and oxidative stress in PD, including the mechanism by which these processes lead to cell death, before assessing the current pharmacotherapies aimed at restoring normal iron redox and new chelation strategies undergoing research.
American Psychological Association (APA)
Mounsey, Ross B.& Teismann, Peter. 2012. Chelators in the Treatment of Iron Accumulation in Parkinson's Disease. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-513473
Modern Language Association (MLA)
Mounsey, Ross B.& Teismann, Peter. Chelators in the Treatment of Iron Accumulation in Parkinson's Disease. International Journal of Cell Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-513473
American Medical Association (AMA)
Mounsey, Ross B.& Teismann, Peter. Chelators in the Treatment of Iron Accumulation in Parkinson's Disease. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-513473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513473