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Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase
Joint Authors
Finarov, Igal
Klipcan, Liron
Moor, Nina
Safro, Mark G.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aminoacyl-tRNA synthetases (aaRSs) are a canonical set of enzymes that specifically attach corresponding amino acids to their cognate transfer RNAs in the cytoplasm, mitochondria, and nucleus.
The aaRSs display great differences in primary sequence, subunit size, and quaternary structure.
Existence of three types of phenylalanyl-tRNA synthetase (PheRS)—bacterial (αβ)2, eukaryotic/archaeal cytosolic (αβ)2, and mitochondrial α—is a prominent example of structural diversity within the aaRSs family.
Although archaeal/eukaryotic and bacterial PheRSs share common topology of the core domains and the B3/B4 interface, where editing activity of heterotetrameric PheRSs is localized, the detailed investigation of the three-dimensional structures from three kingdoms revealed significant variations in the local design of their synthetic and editing sites.
Moreover, as might be expected from structural data eubacterial, Thermus thermophilus and human cytoplasmic PheRSs acquire different patterns of tRNAPhe anticodon recognition.
American Psychological Association (APA)
Klipcan, Liron& Finarov, Igal& Moor, Nina& Safro, Mark G.. 2010. Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase. Journal of Amino Acids،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-513492
Modern Language Association (MLA)
Klipcan, Liron…[et al.]. Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase. Journal of Amino Acids No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-513492
American Medical Association (AMA)
Klipcan, Liron& Finarov, Igal& Moor, Nina& Safro, Mark G.. Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase. Journal of Amino Acids. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-513492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513492