Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress
Joint Authors
Kim, Ki Cheon
Jung, Eunsun
Kim, Daeshin
Hyun, Jin Won
Park, Deokhoon
Kim, Sang Cheol
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes.
An ethyl acetate extract of E.
nigrum (ENE) increased cell viability decreased by exposure to UVB rays.
ENE also absorbed UVB radiation and scavenged UVB-induced intracellular reactive oxygen species (ROS) in HaCaT keratinocytes.
In addition, ENE shielded HaCaT keratinocytes from damage to cellular components (e.g., peroxidation of lipids, modification of proteins, and breakage of DNA strands) following UVB irradiation.
Furthermore, ENE protected against UVB-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies and sub-G1 hypodiploid cells, as well as by the recovery of mitochondrial membrane potential.
The results of the current study therefore suggest that ENE safeguards human keratinocytes against UVB-induced cellular damage via the absorption of UVB ray and scavenging of UVB-generated ROS.
American Psychological Association (APA)
Kim, Ki Cheon& Kim, Daeshin& Kim, Sang Cheol& Jung, Eunsun& Park, Deokhoon& Hyun, Jin Won. 2013. Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513505
Modern Language Association (MLA)
Kim, Ki Cheon…[et al.]. Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-513505
American Medical Association (AMA)
Kim, Ki Cheon& Kim, Daeshin& Kim, Sang Cheol& Jung, Eunsun& Park, Deokhoon& Hyun, Jin Won. Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513505