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Molecular Diversity of the Antimicrobial Domain of Beta-Defensin 3 and Homologous Peptides
Joint Authors
Escorcia, Magdalena
Nava, Gerardo M.
Castañeda, M. Pilar
Source
Comparative and Functional Genomics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Human β-defensin 3 has received great interest for possible pharmaceutical applications.
To characterize the biology of this antimicrobial peptide, the mouse β-defensin 14 has been selected as a prototypical model.
This report provides definite evidence of true orthology between these defensins and reveals molecular diversity of a mammalian specific domain responsible for their antimicrobial activity.
Specifically, this analysis demonstrates that eleven amino acid residues of the antimicrobial domain have been mutated by positive selection to confer protein niche specialization.
These data support the notion that natural selection acts as evolutionary force driving the proliferation and diversification of defensins and introduce a novel strategy for the design of more effective antibiotics.
American Psychological Association (APA)
Nava, Gerardo M.& Escorcia, Magdalena& Castañeda, M. Pilar. 2009. Molecular Diversity of the Antimicrobial Domain of Beta-Defensin 3 and Homologous Peptides. Comparative and Functional Genomics،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-513507
Modern Language Association (MLA)
Nava, Gerardo M.…[et al.]. Molecular Diversity of the Antimicrobial Domain of Beta-Defensin 3 and Homologous Peptides. Comparative and Functional Genomics No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-513507
American Medical Association (AMA)
Nava, Gerardo M.& Escorcia, Magdalena& Castañeda, M. Pilar. Molecular Diversity of the Antimicrobial Domain of Beta-Defensin 3 and Homologous Peptides. Comparative and Functional Genomics. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-513507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513507