Microglia, Alzheimer's Disease, and Complement
Joint Authors
Crehan, Helen
Hardy, John
Pocock, Jennifer
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Microglia, the immune cell of the brain, are implicated in cascades leading to neuronal loss and cognitive decline in Alzheimer’s disease (AD).
Recent genome-wide association studies have indicated a number of risk factors for the development of late-onset AD.
Two of these risk factors are an altered immune response and polymorphisms in complement receptor 1.
In view of these findings, we discuss how complement signalling in the AD brain and microglial responses in AD intersect.
Dysregulation of the complement cascade, either by changes in receptor expression, enhanced activation of different complement pathways or imbalances between complement factor production and complement cascade inhibitors may all contribute to the involvement of complement in AD.
Altered complement signalling may reduce the ability of microglia to phagocytose apoptotic cells and clear amyloid beta peptides, modulate the expression by microglia of complement components and receptors, promote complement factor production by plaque-associated cytokines derived from activated microglia and astrocytes, and disrupt complement inhibitor production.
The evidence presented here indicates that microglia in AD are influenced by complement factors to adopt protective or harmful phenotypes and the challenge ahead lies in understanding how this can be manipulated to therapeutic advantage to treat late onset AD.
American Psychological Association (APA)
Crehan, Helen& Hardy, John& Pocock, Jennifer. 2012. Microglia, Alzheimer's Disease, and Complement. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513508
Modern Language Association (MLA)
Crehan, Helen…[et al.]. Microglia, Alzheimer's Disease, and Complement. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-513508
American Medical Association (AMA)
Crehan, Helen& Hardy, John& Pocock, Jennifer. Microglia, Alzheimer's Disease, and Complement. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513508