Impedance-Based Miniaturized Biosensor for Ultrasensitive and Fast Prostate-Specific Antigen Detection
Joint Authors
Arya, Sunil K.
Tanner, Richard
Bhansali, Shekhar
Chornokur, Ganna
Phelan, Catherine M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This paper reports the successful fabrication of an impedance-based miniaturized biosensor and its application for ultrasensitive Prostate-Specific Antigen (PSA) detection in standard and real human plasma solution, spiked with different PSA concentrations.
The sensor was fabricated using photolithographic techniques, while monoclonal antibodies specific to human PSA were used as primary capture antibodies.
Electrochemical impedance spectroscopy (EIS) was employed as a detection technique.
The sensor exhibited a detection limit of 1 pg/ml for PSA with minimal nonspecific binding (NSB).
This detection limit is an order of magnitude lower than commercial PSA ELISA assays available on the market.
The sensor can be easily modified into an array for the detection of other biomolecules of interest, enabling accurate, ultrasensitive, and inexpensive point-of-care sensing technologies.
American Psychological Association (APA)
Chornokur, Ganna& Arya, Sunil K.& Phelan, Catherine M.& Tanner, Richard& Bhansali, Shekhar. 2011. Impedance-Based Miniaturized Biosensor for Ultrasensitive and Fast Prostate-Specific Antigen Detection. Journal of Sensors،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513518
Modern Language Association (MLA)
Chornokur, Ganna…[et al.]. Impedance-Based Miniaturized Biosensor for Ultrasensitive and Fast Prostate-Specific Antigen Detection. Journal of Sensors No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-513518
American Medical Association (AMA)
Chornokur, Ganna& Arya, Sunil K.& Phelan, Catherine M.& Tanner, Richard& Bhansali, Shekhar. Impedance-Based Miniaturized Biosensor for Ultrasensitive and Fast Prostate-Specific Antigen Detection. Journal of Sensors. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513518