Oat Attenuation of Hyperglycemia-Induced Retinal Oxidative Stress and NF-κB Activation in Streptozotocin-Induced Diabetic Rats
Author
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The overproduction of reactive oxygen species (ROS) plays a central role in the pathogenesis of endothelial damage in diabetes.
To assess the effect of oat on experimental diabetic retinopathy, five groups of Albino rats were studied: nondiabetic control, untreated diabetic, and diabetic rats treated with 5%, 10%, and 20% (W/W) oat of the diet for 12 weeks.
Novel data were obtained in this study indicating a protective role of oat against oxidative stress and diabetic retinopathy.
The effects of oat on parameters of oxidative stress, AGE, and nuclear factor kappa B (NF-κB) were assessed by ELISA and NF-κB activation by electrophoretic mobility shift assay.
Tumor necrosis factor alpha (TNFα) and vascular endothelial growth factor (VEGF) were also determined.
After 12 weeks of diabetes, oat treatment reduced blood glucose levels, HbA1c, all oxidative stress markers, CML, normalized NF-κB activation and TNFα expression.
Furthermore it reduced VEGF in the diabetic retina by 43% (P<0.001).
In conclusion, oat modulates microvascular damage through normalized pathways downstream of ROS overproduction and reduction of NF-κB and its controlled genes activation, which may provide additional endothelial protection.
American Psychological Association (APA)
al-Malki, Abdulrahman L.. 2013. Oat Attenuation of Hyperglycemia-Induced Retinal Oxidative Stress and NF-κB Activation in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513533
Modern Language Association (MLA)
al-Malki, Abdulrahman L.. Oat Attenuation of Hyperglycemia-Induced Retinal Oxidative Stress and NF-κB Activation in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-513533
American Medical Association (AMA)
al-Malki, Abdulrahman L.. Oat Attenuation of Hyperglycemia-Induced Retinal Oxidative Stress and NF-κB Activation in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513533