Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever
Joint Authors
Olinger, Gene Garrard
Warfield, Kelly Lyn
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Infection with many emerging viruses, such as the hemorrhagic fever disease caused by the filoviruses, Marburg (MARV), and Ebola virus (EBOV), leaves the host with a short timeframe in which to mouse a protective immune response.
In lethal cases, uncontrolled viral replication and virus-induced immune dysregulation are too severe to overcome, and mortality is generally associated with a lack of notable immune responses.
Vaccination studies in animals have demonstrated an association of IgG and neutralizing antibody responses against the protective glycoprotein antigen with survival from lethal challenge.
More recently, studies in animal models of filovirus hemorrhagic fever have established that induction of a strong filovirus-specific cytotoxic T lymphocyte (CTL) response can facilitate complete viral clearance.
In this review, we describe assays used to discover CTL responses after vaccination or live filovirus infection in both animal models and human clinical trials.
Unfortunately, little data regarding CTL responses have been collected from infected human survivors, primarily due to the low frequency of disease and the inability to perform these studies in the field.
Advancements in assays and technologies may allow these studies to occur during future outbreaks.
American Psychological Association (APA)
Warfield, Kelly Lyn& Olinger, Gene Garrard. 2011. Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-513573
Modern Language Association (MLA)
Warfield, Kelly Lyn& Olinger, Gene Garrard. Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-513573
American Medical Association (AMA)
Warfield, Kelly Lyn& Olinger, Gene Garrard. Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-513573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513573