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Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer
Joint Authors
Antenucci, Anna
Huebner, Kay
Conti, Laura
Zanesi, Nicola
Volinia, Stefano
Pekarsky, Yuri
Costinean, Stefan
Aqeilan, Rami I.
Drusco, Alessandra
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chromosomal common fragile sites (CFSs) are specific mammalian genomic regions that show an increased frequency of gaps and breaks when cells are exposed to replication stress in vitro.
CFSs are also consistently involved in chromosomal abnormalities in vivo related to cancer.
Interestingly, several CFSs contain one or more tumor suppressor genes whose structure and function are often affected by chromosomal fragility.
The two most active fragile sites in the human genome are FRA3B and FRA16D where the tumor suppressor genes FHIT and WWOX are located, respectively.
The best approach to study tumorigenic effects of altered tumor suppressors located at CFSs in vivo is to generate mouse models in which these genes are inactivated.
This paper summarizes our present knowledge on mouse models of cancer generated by knocking out tumor suppressors of CFS.
American Psychological Association (APA)
Drusco, Alessandra& Pekarsky, Yuri& Costinean, Stefan& Antenucci, Anna& Conti, Laura& Volinia, Stefano…[et al.]. 2011. Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-513599
Modern Language Association (MLA)
Drusco, Alessandra…[et al.]. Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-513599
American Medical Association (AMA)
Drusco, Alessandra& Pekarsky, Yuri& Costinean, Stefan& Antenucci, Anna& Conti, Laura& Volinia, Stefano…[et al.]. Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-513599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513599